Dr. Iris Grothe

Fries Lab · Alumni

Research statement

Selective attention allows us to respond to relevant, while ignoring irrelevant information. To understand how this works at the neuronal level is a particularly challenging question due to the dense connectivity of neurons. How is the meaningful subset of neuronal signals selected from the large mass? Note that signal selection is essential at different levels of computation, from the single neuron level up to interacting brain areas. Synchronized activity between neurons has been put forward as a potential mechanism of selective information routing. My research aims to understand the mechanisms involved in generating selective interareal synchrony. Currently, I am employing simultaneous large scale laminar recordings in multiple visual areas. This will allow us to map the laminar profile of interareal interactions. In addition, we will further characterize these interareal interactions through pharmacological intervention.

Key publications

Grothe, I., Neitzel, S. D., Mandon, S., Kreiter, A. K. (2012) Switching Neuronal Inputs by Differential Modulations of Gamma-Band Phase-Coherence. Journal of Neuroscience 32(46), 16172-16180. DOI

Grothe, I., Rotermund, D., Neitzel, S. D., Mandon, S., Ernst, U. A., Kreiter, A. K., & Pawelzik, K. R. (2018). Attention selectively gates afferent signal transmission to area V4. Journal of Neuroscience, 38(14), 3441-3452. DOI